Synthroid Levothyroxine Sodium: Side Effects, Uses, Dosage, Interactions, Warnings

This is important because the amount of medicine you need is very precise. And even the way you take Synthroid can affect how much medicine your body is getting. It’s important to always take your medication exactly as your doctor prescribed.

Levothyroxine (oral route)

Absorption of orally administered T4 from the gastrointestinal tract ranges from 40% to 80%. The majority of the SYNTHROID dose is absorbed from the jejunum and upper ileum. The relative bioavailability of SYNTHROID tablets, compared to an equal nominal dose of oral levothyroxine sodium solution, is approximately 93%.

Hypothyroidism

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your thyroid hormone levels and also make levothyroxine less effective. SYNTHROID increases the response to oral anticoagulant therapy. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the SYNTHROID dose is increased.

Carefully monitor glycemic control, especially when thyroid therapy is started, changed, or discontinued see WARNINGS AND PRECAUTIONS. Many other medicines can be affected by your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of Synthroid.

This medicine will need to be taken for the rest of your life or your child’s life. Do not stop taking this medicine or change your dose without first checking with your doctor. You may have to take this medicine for 4 to 8 weeks before your symptoms start to get better.

Careful dose titration is necessary to avoid the consequences of

You may be more likely to have a broken bone while using levothyroxine. You should not use levothyroxine if you are allergic to glycerin or edetate disodium, or if you have an untreated or uncontrolled adrenal gland disorder. Armour Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid …

Dosing Considerations

There are certain populations where we pay closer attention to thyroid medication dosing. Another group is those synthroid bloating that have underlying cardiac disease or are at risk for atrial fibrillation. And a third is those that have severe, long-standing hypothyroidism. Family history is very important when talking to these patients because there is a strong predisposition amongst family members in the primary setting to have another family member with hypothyroidism.

Closely monitor infants during the first 2 weeks of SYNTHROID therapy for cardiac overload and arrhythmias. Concurrent use of ketamine and SYNTHROID may produce marked hypertension and tachycardia. Closely monitor blood pressure and heart rate in these patients. Seizures have been reported rarely with the institution of levothyroxine therapy. Values below the range may indicate hypofunctioning thyroid, which may be seen in hypothyroidism, factitious exogenous thyroid use, or thyroiditis. Inadequate diet preparation may also falsely lower I-123 uptake 4.

Drug Interactions for Synthroid

• That is primary, secondary, or tertiary hypothyroidism, either due to congenital or acquired state.
• Consider the potential for food or drug interactions and adjust the administration or dosage of SYNTHROID as needed see Dosage and Administration (2.1), Drug Interactions (7.1), and Clinical Pharmacology (12.3).
• Medications that interfere with thyroid uptake of radioiodine should be discontinued.
• AbbVie is dedicated to ensuring that all SYNTHROID products are manufactured at the highest standards.
• Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

It is meant to replace a hormone that is usually made by your thyroid gland. Generally, thyroid replacement treatment is to be taken for life. SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland (thyroiditis). The recommended starting daily dosage of SYNTHROID in pediatric patients with primary, secondary, or tertiary hypothyroidism is based on body weight and changes with age as described in Table 2.

Because of the increased prevalence of cardiovascular disease among the elderly, initiate SYNTHROID at less than the full replacement dose see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS. Initiate SYNTHROID therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease see DOSAGE AND ADMINISTRATION and Use In Specific Populations. Assess the adequacy of therapy by periodic assessment of laboratory tests and clinical evaluation. Persistent clinical and laboratory evidence of hypothyroidism despite an apparent adequate replacement dose of SYNTHROID may be evidence of inadequate absorption, poor compliance, drug interactions, or a combination of these factors. For adult patients with primary hypothyroidism, titrate until the patient is clinically euthyroid and the serum TSH returns to normal see Recommended Dosage And Titration.